M. Lamb

De novo design of buttressed loops for sculpting protein functions

This paper designs proteins with structured loops supported by hydrogen bonds, demonstrating their stability and functionality in binding extended peptides.

Computational design of non-porous, pH-responsive antibody nanoparticles

This paper designs pH-responsive antibody nanoparticles with three distinct protein components that disassemble at tunable pH levels, enabling targeted delivery of biologics.

Design of stimulus-responsive two-state hinge proteins

This paper designs two-state hinge proteins that switch between structural states in response to ligands, demonstrating atomic-level accuracy and tunable kinetics and thermodynamics.

De novo design of high-affinity protein binders to bioactive helical peptides

This paper designs high-affinity protein binders for bioactive helical peptides using deep learning and generative models, achieving picomolar affinity without experimental optimization.

Precisely patterned nanofibers made from extendable protein multiplexes

The paper designs extendable protein multiplexes with symmetric architectures to create precisely patterned nanofibers through controlled repeat propagation and hydrophilic patch placement.

Lung Tumor Microphysiological System with 3D Endothelium to Evaluate Modulators of T-Cell Infiltration

This paper introduces a 3D lung tumor on chip model with endothelium to evaluate T-cell infiltration modulators and demonstrates its utility in assessing immune chemotaxis and vascular responses.