P.-S. Huang

This paper introduces photoswitchable DARPins (psDARPins) for optical control of endogenous protein function, demonstrating their use in inhibiting ERK and Ras and studying EGFR to ERK signaling.

This paper introduces an all-atom diffusion model for protein structure generation that co-designs structure and sequence, producing high-quality proteins with accurate sidechain behavior.

This paper designs a protein family with two structurally divergent folds, showing that sequences can adopt distinct conformations under different conditions.

This study determines the crystal structure of human VISTA and identifies its binding epitope for an anti-VISTA antibody and VSIG3.