Author

M. Kadam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Kumar· 3 shared D. Y. Patil· 3 shared P. D. Yadav· 3 shared S. Mohandas· 3 shared A. M. Shete· 2 shared D. A. Nyayanit· 2 shared G. Deshpande· 2 shared G. Sapkal· 2 shared

Activity by Year

2021-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

A. Kumar

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Pathogenicity of SARS-CoV-2 Omicron in Syrian hamsters and its neutralization with different Variants of Concern

S. Mohandas, P. D. Yadav, G. Sapkal, A. M. Shete, G. Deshpande, D. A. Nyayanit, D. Y. Patil, M. Kadam, A. Kumar, C. Mote, R. Jain

This study evaluates the pathogenicity of SARS-CoV-2 Omicron BA.1 in Syrian hamsters and finds reduced cross-neutralization against other variants.

bioRxiv · Jan 19, 2022 · PreprintMicrobiology

Qualifying a human Liver-Chip for predictive toxicology: Performance assessment and economic implications

L. Ewart, A. Apostolou, S. A. Briggs, C. V. Carman, J. T. Chaff, A. R. Heng, S. Jadalannagari, J. Janardhanan, K.-J. Jang, S. R. Joshipura, M. Kadam, M. Kanellias, V. J. Kujala, G. Kulkarni, C. Y. Le, , D. Levner

The paper evaluates a Liver-Chip's ability to predict drug-induced liver injury and estimates its economic impact in pharmaceutical R&D.

bioRxiv · Dec 14, 2021 · PreprintPharmacology & Toxicology

SARS CoV-2 variant B.1.617.1 is highly pathogenic in hamsters than B.1 variant

P. D. Yadav, S. Mohandas, A. M. Shete, D. A. Nyayanit, N. Gupta, D. Y. Patil, G. N. Sapkal, V. Potdar, M. Kadam, A. kumar, S. Kumar, D. Suryavanshi, C. S. Mote, P. Abraham, S. Panda, B. Bhargava

This study compares the pathogenicity of SARS-CoV-2 variants B.1 and B.1.617.1 in hamsters, finding B.1.617.1 causes greater body weight loss, higher viral load, and more severe lung lesions.

bioRxiv · May 5, 2021 · PreprintMicrobiology

Vaccine Hyporesponse Induced By Individual Antibiotic Treatment In Mice And Non-Human Primates Is Diminished Upon Recovery Of The Gut Microbiome

G. Swaminathan, M. Citron, J. Xiao, J. E. Norton, A. L. Reens, B. D. Topcuoglu, J. M. Maritz, K.-J. Lee, D. Freed, T. M. Weber, C. H. White, M. Kadam, E. Spofford, E. Bryant-Hall, G. Salituro, , G. D. Hannigan

This study shows that antibiotic-induced gut microbiome disruption reduces vaccine response in mice and non-human primates, but recovery of microbiome diversity restores immune responses.

bioRxiv · Apr 2, 2021Immunology

Comparison of the pathogenicity and virus shedding of SARS CoV-2 VOC 202012/01 and D614G variant in hamster model

S. Mohandas, P. D. Yadav, D. Nyayanit, G. Deshpande, A. S. Aich, G. Sapkal, S. Kumar, R. Jain, M. Kadam, A. Kumar, D. Y. Patil, P. Sarkale, P. Gawande, P. Abraham

This study compares the pathogenicity and virus shedding of SARS-CoV-2 VOC 202012/01 and D614G variants in hamsters, finding higher viral shedding and mild lung pathology with VOC 202012/01.

bioRxiv · Feb 25, 2021 · PreprintMicrobiology