S. Panda

Intra-DNA k-mer Conservation Patterns Encode Evolutionary Selection of Variants

The paper introduces kGain, a metric quantifying k-mer frequency shifts due to mutations, and shows it predicts adaptive potential across species and experimental systems.

Purifying selection and intraspecies recombination may drive the speciation in Crassostrea: evidence from complete mitochondria sequence of Crassostrea hongkongensis and comparative genomic analysis

This study analyzes the mitochondrial genome of Crassostrea hongkongensis and finds evidence of purifying selection and intraspecific recombination in its evolution.

Remodeling Ca2+ dynamics by targeting a promising E-box containing G-quadruplex at ORAI1 promoter in triple-negative breast cancer.

The paper identifies a G-quadruplex in the ORAI1 promoter that regulates transcription and Ca2+ dynamics in triple-negative breast cancer.

In Silico designed cell-penetrating anti-cancer peptide specifically inhibits VEGF-A expression

The paper designs in silico peptides that stabilize VEGF-A G-quadruplexes, reducing gene expression and inhibiting angiogenesis in cancer cells.

ALTering cancer by triggering telomere replication stress through the stabilization of promoter G-quadruplex in SMARCAL1

This study shows that stabilizing G-quadruplex in SMARCAL1 promoter reduces its expression, increases replication stress, and promotes DNA damage in ALT-positive cancer cells, suggesting G4 stabilizers as potential therapeutics.

Staphylococcus aureus counters organic acid anion-mediated inhibition of peptidoglycan cross-linking through robust alanine racemase activity

This study shows that Staphylococcus aureus counters acetate-mediated inhibition of peptidoglycan cross-linking by maintaining high intracellular D-Ala levels through alanine racemase and limiting D-Ala flux via D-alanine aminotransferase.

First complete genome characterization of an Indian pigeon pox virus directly from a clinical sample

The paper reports the first complete genome of an Indian pigeon pox virus and performs comparative genomics analysis to understand its genetic features and phylogenetic relationships.

Identification of differentially recognized T cell epitopes in the spectrum of Mtb infection

The paper identifies differentially recognized T cell epitopes in Mtb infection stages using a proteome-wide screen and Fluorospot assay, revealing epitopes specific to active TB and potential vaccine targets.

Inferring B-cell derived T-cell receptor induced multi epitope-based vaccine candidate against enterovirus 71 (EV 71): A reverse vaccinology approach.

This study uses reverse vaccinology to design a multi-epitope vaccine against EV71, showing high immunogenicity and safety through computational analysis.

Engineering Escherichia coli to produce aromatic chemicals from ethylene glycol

This study engineers Escherichia coli to produce aromatic chemicals from ethylene glycol, achieving higher yields than glucose and demonstrating feasibility with waste PET-derived EG.

Genomewide basis for nitrogen use efficiency in contrasting genotypes of rice

This study compares transcriptomes of rice genotypes with contrasting nitrogen use efficiency under urea treatment, identifying common and specific gene expression patterns and their association with agronomic performance.

Cross regulation between the molecular clock and kidney inflammatory, metabolic and fibrotic responses

This study investigates the interaction between the molecular clock and kidney fibrosis in experimental models, finding that clock components influence inflammation and fibrosis, while fibrosis alters clock gene expression.

Chronic hyperglycemia drives alterations in macrophage effector function in pulmonary tuberculosis

This study examines how chronic hyperglycemia affects macrophage effector functions in pulmonary tuberculosis, finding reduced phagocytic capacity and altered PRR expression in diabetic TB patients.

Neutralization of Delta variant with sera of Covishield vaccinees and COVID-19 recovered vaccinated individuals

This study evaluates immune response in Covishield vaccinated and recovered individuals against the Delta variant, finding higher protection in breakthrough cases and recovered individuals compared to single or double vaccinated groups.

Neutralization against B.1.351 and B.1.617.2 with sera of COVID-19 recovered cases and vaccinees of BBV152

This study assesses the neutralization efficacy of sera from COVID-19 recovered cases and BBV152 vaccinees against SARS-CoV-2 variants B.1.351 and B.1.617.2, showing reduced titers but still protective responses.

Isolation of SARS-CoV-2 B.1.1.28.2 P2 variant and pathogenicity comparison with D614G variant in hamster model

The paper isolates the SARS-CoV-2 B.1.1.28.2 (P.2) variant from travelers and compares its pathogenicity to the D614G variant in hamsters, finding it more severe and with reduced neutralization.

Neutralization potential of Covishield vaccinated individuals sera against B.1.617.1

This study compares neutralizing antibody responses in Covishield-vaccinated individuals and COVID-19 recovered subjects against B.1 and B.1.617.1 variants, finding higher neutralization in recovered subjects.

SARS CoV-2 variant B.1.617.1 is highly pathogenic in hamsters than B.1 variant

This study compares the pathogenicity of SARS-CoV-2 variants B.1 and B.1.617.1 in hamsters, finding B.1.617.1 causes greater body weight loss, higher viral load, and more severe lung lesions.

Neutralization of B.1.1.28 P2 variant with sera of natural SARS-CoV-2 infection and recipients of BBV152 vaccine

This study evaluates the neutralizing efficacy of B.1.1.28.2 variant against sera from natural infection and BBV152 vaccine recipients, showing reduced neutralization compared to D614G.

Neutralization of variant under investigation B.1.617 with sera of BBV152 vaccinees

The paper assesses the neutralizing ability of sera from BBV152 vaccinees and convalescent COVID-19 patients against B.1.617 variants.

The innate immune DNA sensor cGAS is a negative regulator of DNA repair hence promotes genome instability and cell death

This study identifies cGAS as a negative regulator of homologous recombination DNA repair, leading to genome instability and cell death.