S. Falk

MUT-7 exoribonuclease activity and localisation are mediated by an ancient domain

This study identifies two functions of the MUT7-C domain: RNA binding and recruitment to germ granules, revealing its ancestral role in MUT-7 exoribonuclease activity.

Alternative mRNA splicing controls the functions of the histone H3K27 demethylase UTX/KDM6A

The paper identifies extensive alternative splicing in UTX/KDM6A mRNAs that affects subcellular localization and interactions with chromatin regulatory complexes.

Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancer

The paper identifies three subtypes of MMR deficient colorectal cancer based on genetic and immune landscape evolution, linking them to T-cell infiltrates and checkpoint-inhibitor resistance.

A Modified TurboID Approach Identifies Tissue-Specific Centriolar Components In C. elegans

The paper modifies TurboID to identify tissue-specific centriolar components in C. elegans using GFP nanobody fusion, revealing conserved proteins absent in early embryos.

The CHK-2 antagonizing phosphatase PPM-1.D regulates meiotic entry via catalytic and non-catalytic activities

The paper identifies PPM-1.D as a phosphatase that antagonizes CHK-2 kinase to regulate meiotic entry through both catalytic and non-catalytic mechanisms.

Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans

The paper determines the structure of the PETISCO complex in C. elegans and elucidates its role in piRNA biogenesis and early embryogenesis.

Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

The paper shows that exercise increases circulating GDF15 levels, but this physiological increase does not suppress appetite or exercise motivation like pharmacological GDF15.