M. Kuraoka

This paper identifies a class of antibodies that neutralize both H1 and H3 influenza viruses by overcoming a steric barrier at the HA RBS.

This study shows that an epitope-enriched immunogen preferentially expands RBS-directed antibody responses compared to non-enriched immunogens.

This paper studies how influenza vaccination in infants shapes their antibody responses, finding that vaccination can lead to immune imprinting similar to infection, with shifts in B-cell specificity and adult-like antibody repertoires after the second year.

The study shows that memory B cells form recall germinal centers more effectively when boosts are given at the same site as the initial immunization, leading to higher mutation levels and avidity in BCRs.

The paper identifies a focused, protective antibody response targeting a conserved region at the influenza hemagglutinin head interface, showing cross-serotype binding and potential for durable immunity.

This paper describes the engineering of immunogens that present a conserved viral epitope using avian influenza HAs, showing they are immunogenic and can enrich for RBS-directed antibodies.