G. Bajic

Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination

This study identifies non-neutralizing antibodies from vaccinated individuals that protect against SARS-CoV-2 in animal models, highlighting their role through Fc-mediated effector functions and conserved epitope binding.

An in vitro experimental pipeline to characterize the binding specificity of SARS-CoV-2 neutralizing antibodies

This paper characterizes the binding specificity and epitope of a broadly neutralizing anti-SARS-CoV-2 Spike RBD antibody using mAb-resistant virions and cryo-EM structural analysis.

Infant antibody repertoires during the first two years of influenza vaccination

This paper studies how influenza vaccination in infants shapes their antibody responses, finding that vaccination can lead to immune imprinting similar to infection, with shifts in B-cell specificity and adult-like antibody repertoires after the second year.

Recall of B cell memory depends on relative locations of prime and boost

The study shows that memory B cells form recall germinal centers more effectively when boosts are given at the same site as the initial immunization, leading to higher mutation levels and avidity in BCRs.

SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage

This study shows SARS-CoV-2 variants of concern have mutations that increase spike cleavage and fusogenic capacity, enhancing viral transmission and cell entry.

Structure of a germline-like human antibody defines a neutralizing epitope on the SARS-CoV-2 spike NTD

The paper structures a germline-like antibody in complex with SARS-CoV-2 spike NTD, revealing a neutralizing epitope and its conservation across variants.

A public vaccine-induced human antibody protects against SARS-CoV-2 and emerging variants

A vaccine-induced human monoclonal antibody neutralizes SARS-CoV-2 and variants, reducing lung inflammation and viral load in hamsters.

Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike

The paper maps memory B cell receptors against SARS-CoV-2 spike variants, identifying 7 mAb competition groups and their epitopic regions, and shows their cross-reactivity and neutralization properties.

Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses

The paper isolates naive B cells targeting SARS-CoV-2 RBD and shows they can neutralize the virus and variants.

Complement receptor 3 forms a compact high affinity complex with iC3b

This study shows that CR3 forms a high-affinity complex with iC3b, which enhances phagocytosis and informs therapeutic development.

Structure-guided molecular grafting of a complex broadly neutralizing viral epitope

This paper describes the engineering of immunogens that present a conserved viral epitope using avian influenza HAs, showing they are immunogenic and can enrich for RBS-directed antibodies.