Cancer BiologybioRxiv
Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer
B. P. Brown, Y. Zhang, S. Kim…·C. M. Lovly
The paper identifies allele-specific functional differences among EGFR exon 19 deletion variants, showing how sequence and structure motifs affect oncogenic activity, dimerization, and TKI sensitivity.
DOI 10.1073/pnas.2206588119