Human Tau Isoform Aggregation and Selective Detection of Misfolded Tau from Post-Mortem Alzheimer's Disease Brains
L. Wu, Z. Wang, S. Lad, D. Dougharty, S. Madhavan, M. Marcus, F. Henderson, W. K. Ray, C. Tan, S. Siedlak, J. Li, R. F. Helm, X. Zhu, G. S. Bloom, W. Zou, B. Xu
This study investigates human tau isoform aggregation in Alzheimer's disease, showing 3R tau aggregates faster than 4R and identifies key domains for aggregation, while demonstrating the use of RT-QuIC to detect misfolded tau.
bioRxiv · Dec 31, 2019 · PreprintPathology