R. F. Helm

Identification of a new family of peptidoglycan transpeptidases reveals atypical crosslinking is essential for viability in Clostridioides difficile

This study identifies a new family of LDTs in C. difficile that catalyze 3-3 peptidoglycan crosslinking, essential for viability and distinct from previously known YkuD domain LDTs.

CADD from Chlamydia trachomatis is a manganese-dependent oxygenase that employs a self-sacrificing mechanism for the synthesis of p-aminobenzoate

This study characterizes CADD from Chlamydia trachomatis as a manganese-dependent oxygenase using self-sacrificing tyrosine and lysine residues for p-aminobenzoate synthesis.

Comparative metabolomics of fruits and leaves in a hyperdiverse lineage suggests fruits are a key incubator of phytochemical diversification

The paper compares metabolomics of fruits and leaves in Piper species, finding fruits have higher phytochemical diversity and variability than leaves.

Catechol-Containing Compounds are a Broad Class of Amyloid Inhibitors: Redox State is a Key Determinant of the Inhibitory Activities

The paper identifies catechol-containing compounds as broad amyloid inhibitors and shows redox state determines their activity.

Human Tau Isoform Aggregation and Selective Detection of Misfolded Tau from Post-Mortem Alzheimer's Disease Brains

This study investigates human tau isoform aggregation in Alzheimer's disease, showing 3R tau aggregates faster than 4R and identifies key domains for aggregation, while demonstrating the use of RT-QuIC to detect misfolded tau.