Author

M. Niello

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

H. H. Sitte· 2 shared M. Freissmuth· 2 shared W. Sandtner· 2 shared A. S. Alberto-Silva· 1 shared C. Pifl· 1 shared D. Boytsov· 1 shared E. Bossi· 1 shared E. Hellsberg· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPharmacology & Toxicology

H. H. Sitte

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Identification of the potassium binding site in serotonin transporter SERT

E. Hellsberg, D. Boytsov, Q. Chen, M. Niello, M. Freissmuth, G. Rudnick, Y.-W. Zhang, W. Sandtner, L. R. Forrest

This study identifies the Na2 site as the potassium binding site in SERT using molecular dynamics simulations and site-directed mutagenesis.

Proceedings of the National Academy of Sciences · Apr 23, 2024Peer-reviewedBiochemistry

Bioisosteric analogs of MDMA with improved pharmacological profile

A. S. Alberto-Silva, S. Hemmer, H. A. Bock, L. Alves da Silva, K. R. Scott, N. Kastner, M. Bhatt, M. Niello, K. Jantsch, O. Kudlacek, E. Bossi, T. Stockner, M. R. Meyer, J. D. McCorvy, S. D. Brandt, , H. H. Sitte

This study evaluates three MDMA bioisosteres for improved pharmacological profiles, finding reduced off-target receptor activity and altered hepatic metabolism compared to MDMA.

bioRxiv · Apr 8, 2024 · PreprintPharmacology & Toxicology

Handling of intracellular K + determines voltage dependence of plasmalemmal monoamine transporter function

W. Sandtner, S. Bhat, M. Niello, K. Schicker, C. Pifl, H. H. Sitte, M. Freissmuth

The paper investigates how intracellular K+ handling affects voltage dependence of monoamine transporter function, finding differences between DAT/NET and SERT.

bioRxiv · Mar 11, 2021Biophysics