Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
E. Hellsberg, D. Boytsov, Q. Chen, M. Niello, M. Freissmuth, G. Rudnick, Y.-W. Zhang, W. Sandtner, L. R. Forrest
This study identifies the Na2 site as the potassium binding site in SERT using molecular dynamics simulations and site-directed mutagenesis.
Proceedings of the National Academy of Sciences · Apr 23, 2024Peer-reviewedBiochemistry
S. Bhat, A. Elkasaby, A. Kasture, D. Boytsov, J. B. Reichelt, T. Hummel, S. Sucic, C. Pifl, M. Freissmuth, W. Sandtner
This paper identifies ECSI#6 as an uncompetitive inhibitor of the serotonin transporter, showing it preferentially binds to the K+-bound inward-facing conformation and acts as a pharmacochaperone for misfolded variants.
bioRxiv · Aug 11, 2022Pharmacology & Toxicology
W. Sandtner, S. Bhat, M. Niello, K. Schicker, C. Pifl, H. H. Sitte, M. Freissmuth
The paper investigates how intracellular K+ handling affects voltage dependence of monoamine transporter function, finding differences between DAT/NET and SERT.
bioRxiv · Mar 11, 2021Biophysics
W. Sandtner, V. Burtscher, M. Hotka, M. Freissmuth
This paper introduces an electrophysiological method to detect real-time changes in membrane surface potential and distinguish them from changes in membrane capacitance.
bioRxiv · Apr 12, 2019Biophysics
V. Burtscher, M. Hotka, Y. Li, M. Freissmuth, W. Sandtner
The paper demonstrates a label-free method to detect ligand binding to cell surface proteins by monitoring membrane capacitance changes in real time using the serotonin transporter as a model.
bioRxiv · Jan 22, 2018Biophysics