Author

C. Pifl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:electrophysiology· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:Drosophila· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

M. Freissmuth· 2 shared S. Bhat· 2 shared W. Sandtner· 2 shared A. Elkasaby· 1 shared A. Kasture· 1 shared D. Boytsov· 1 shared H. H. Sitte· 1 shared J. B. Reichelt· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPharmacology & Toxicology

M. Freissmuth

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2 papers

Recent·Most cited

A mechanism of uncompetitive inhibition of the serotonin transporter

S. Bhat, A. Elkasaby, A. Kasture, D. Boytsov, J. B. Reichelt, T. Hummel, S. Sucic, C. Pifl, M. Freissmuth, W. Sandtner

This paper identifies ECSI#6 as an uncompetitive inhibitor of the serotonin transporter, showing it preferentially binds to the K+-bound inward-facing conformation and acts as a pharmacochaperone for misfolded variants.

bioRxiv · Aug 11, 2022Pharmacology & Toxicology

Handling of intracellular K + determines voltage dependence of plasmalemmal monoamine transporter function

W. Sandtner, S. Bhat, M. Niello, K. Schicker, C. Pifl, H. H. Sitte, M. Freissmuth

The paper investigates how intracellular K+ handling affects voltage dependence of monoamine transporter function, finding differences between DAT/NET and SERT.

bioRxiv · Mar 11, 2021Biophysics