M. Freissmuth

Identification of the potassium binding site in serotonin transporter SERT

This study identifies the Na2 site as the potassium binding site in SERT using molecular dynamics simulations and site-directed mutagenesis.

A mechanism of uncompetitive inhibition of the serotonin transporter

This paper identifies ECSI#6 as an uncompetitive inhibitor of the serotonin transporter, showing it preferentially binds to the K+-bound inward-facing conformation and acts as a pharmacochaperone for misfolded variants.

Handling of intracellular K + determines voltage dependence of plasmalemmal monoamine transporter function

The paper investigates how intracellular K+ handling affects voltage dependence of monoamine transporter function, finding differences between DAT/NET and SERT.

A tropane-based ibogaine analog rescues folding-deficient SERT and DAT

The paper identifies a tropane-based ibogaine analog that rescues folding-deficient SERT and DAT mutants in vitro and in vivo.

An electrophysiological approach to measure changes in the membrane surface potential in real time

This paper introduces an electrophysiological method to detect real-time changes in membrane surface potential and distinguish them from changes in membrane capacitance.

A label-free approach to detect ligand binding to cell surface proteins in real time

The paper demonstrates a label-free method to detect ligand binding to cell surface proteins by monitoring membrane capacitance changes in real time using the serotonin transporter as a model.