Ornithine Lipid is a Partial TLR4 Agonist and NLRP3 Activator
M. Pizzuto, L. Hurtado-Navarro, C. Molina-Lopez, J. Soubhye, M. Gelbcke, S. Rodriguez-Lopez, J.-M. Ruysschaert, K. Schroder, P. Pelegrin
This study identifies ornithine lipid as a partial TLR4 agonist and NLRP3 activator, showing it can replace LPS in phosphate-depleted environments to trigger inflammation.
bioRxiv · Jan 28, 2022Immunology