M. Toyoda

This study isolates and expands hepatic progenitor cells from human ESCs by selecting for drug-metabolizing activity, enabling a stable supply of functional liver cells for therapy and drug testing.

This study investigates the virological characteristics of SARS-CoV-2 Omicron BA.2.75, finding it has higher transmissibility and pathogenicity compared to BA.2 and BA.5, but similar sensitivity to antiviral drugs.

This study identifies the S375F mutation in the Omicron spike protein as responsible for its reduced cleavage efficiency, fusogenicity, and rapid spread.

This study compares the virological characteristics of SARS-CoV-2 BA.2 and BA.1 variants, finding BA.2 has higher transmissibility, different antigenicity, greater replicative capacity, and higher pathogenicity in hamsters.

This study investigates the immune escape, infectivity, and cell-cell fusion properties of SARS-CoV-2 Omicron BA.1 compared to Delta, showing higher ACE2 affinity and antibody evasion but similar antiviral drug efficacy.

The paper hypothesizes that colony-forming units in liver (CFU-L) can quantify the engraftment and functionality of hepatocyte-like cells derived from pluripotent stem cells.

This study develops a method to expand human hepatocytes in vitro using a cell-killing antibiotic, enabling long-term culture and stable supply for drug research.

This study identifies two SARS-CoV-2 mutations, L452R and Y453F, that evade HLA-restricted cellular immunity and increase viral infectivity.

This study shows that Gorlin syndrome patient-derived iPSCs form medulloblastoma in mice, with one tumor showing PTCH1 loss of heterozygosity.

The paper generates an immortalized hepatocyte cell line with high CYP3A4 expression from a DILI patient and shows its prolonged lifespan and drug-metabolism capacity.

This study shows that ammonia treatment enriches hepatocyte-like cells derived from human pluripotent stem cells, which can be propagated long-term in vitro while maintaining liver-specific gene expression.

The paper describes the creation of an immortalized hepatocyte cell line, HepaMN, from biliary atresia tissue and demonstrates its utility for cytochrome P450 induction testing.

The paper compares epigenetic differences in human iPSCs generated by three different vectors and finds Sendai virus generates the fewest aberrant methylation sites.

This study generates ESC-derived CD105+ stromal cells with long-term proliferation and myogenic potential as a cell source for myoblast therapy in muscular disorders.