R. Spreafico

The paper shows host-derived oxidized phospholipids initiate effector-triggered immunity, leading to lethality upon microbial encounter, and demonstrates that blocking oxPLs reduces inflammation and host death.

The paper introduces a universal amplicon sequencing method for microbial communities and applies it to study wetlands, showing monthly microbial variation in the Salton Sea.

This study identifies two siRNA combinations that provide robust prophylactic protection against SARS-CoV-2 in hamsters by reducing viral load and preventing lung pathology.

This paper evaluates the in vitro and in vivo efficacy of dual-action monoclonal antibodies VIR-7831 and VIR-7832 against SARS-CoV-2, showing potent neutralization and reduced viral load in a hamster model.

This study identifies maturation signatures of conventional dendritic cell subtypes in COVID-19, showing that cDC2s exhibit viral sensing and inflammatory activation while losing antigen presentation capacity, correlating with disease severity.

The paper shows the N439K SARS-CoV-2 spike variant maintains replication fitness while evading antibody neutralization.

This study shows that type III interferons from lung dendritic cells damage the epithelial barrier and increase susceptibility to bacterial infections during viral recognition.

This study identifies and characterizes a potent neutralizing antibody, S309, against SARS-CoV-2 and related sarbecoviruses, showing its efficacy in preventing viral entry and potential for therapeutic use.

This study shows that soluble fungal polysaccharides are immunosilent in peripheral tissues but become potent immunogens in draining lymph nodes without requiring dendritic cell migration.