Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited via inotropic effectors
W. Ma, C. L. del Rio, L. Qi, M. Prodanovic, S. Mijailovich, C. Zambataro, H. Gong, R. Shimkunas, S. Gollapudi, S. Nag, T. Irving
This paper shows that mavacamten stabilizes myosin in off states, which can still be recruited by physiological inotropic effectors to maintain cardiac function.
bioRxiv · Apr 10, 2023 · PreprintPhysiology