Author

T. Irving

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Physiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell type annotation· 4 Organism:rat· 4 Research Focus:development & morphogenesis· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

W. Ma· 9 shared H. Gong· 5 shared L. Qi· 2 shared M. Landim-Vieira· 2 shared S. Nag· 2 shared S. Sadayappan· 2 shared T. Song· 2 shared V. Jani· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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9 shared papersBiophysics

W. Ma

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Unlocking the Role of sMyBP-C: A Key Player in Skeletal Muscle Development and Growth

T. Song, J. McNamara, A. Baby, W. Ma, M. Landim-Vieira, S. Natesan, J. R. Pinto, J. N. Lorenz, T. Irving, S. Sadayappan

This study identifies sMyBP-C's critical role in skeletal muscle development and function using gene-edited mouse models, showing its necessity for prenatal and postnatal muscle growth and structural integrity.

bioRxiv · Oct 23, 2023 · PreprintPhysiology

The structural OFF and ON states of myosin can be decoupled from the biochemical super-relaxed and disordered-relaxed states.

W. Ma, V. Jani, T. Song, C. Gao, H. Gong, S. Sadayappan, D. A. Kass, T. Irving

This study decouples structural OFF/ON states from biochemical SRX/DRX states in myosin using X-ray diffraction and ATP assays in porcine myocardium.

bioRxiv · Oct 18, 2023 · PreprintBiophysics

Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited via inotropic effectors

W. Ma, C. L. del Rio, L. Qi, M. Prodanovic, S. Mijailovich, C. Zambataro, H. Gong, R. Shimkunas, S. Gollapudi, S. Nag, T. Irving

This paper shows that mavacamten stabilizes myosin in off states, which can still be recruited by physiological inotropic effectors to maintain cardiac function.

bioRxiv · Apr 10, 2023 · PreprintPhysiology

The distinctive mechanical and structural signatures of residual force enhancement in myofibers

A. L. Hessel, M. Kuehn, B. Palmer, D. Nissen, D. Mishra, V. Joumaa, J. Freundt, W. Ma, K. Nishikawa, T. Irving, W. A. Linke

The paper investigates titin's role in residual force enhancement (RFE) in muscle by analyzing structural changes in myofibers with and without titin cleavage and in a mutant strain.

bioRxiv · Feb 19, 2023 · PreprintPhysiology

Thick Filament Activation Is Different in Fast and Slow-Twitch Skeletal Muscle

H. Gong, W. Ma, M. Regnier, T. Irving

This study uses X-ray diffraction to compare thick filament activation dynamics in fast and slow-twitch rat muscles, finding distinct structural transitions that may explain their differing contraction properties.

bioRxiv · Jul 9, 2022Physiology

Cardiac myosin filaments are directly regulated by calcium

W. Ma, H. Gong, L. Qi, S. Nag, T. Irving

This study shows that cardiac myosin filaments are directly regulated by calcium, transitioning from inactive to active states through structural changes.

bioRxiv · Feb 19, 2022Biophysics

Myofibril orientation as a metric for characterizing heart disease

W. Ma, H. Gong, V. Jani, M. Landim-Vieira, M. Papadaki, J. Pinto, M. I. Aslam, A. Cammarato, T. Irving

This paper introduces a method to quantify myofibrillar orientation in cardiac muscle and shows it detects greater disorientation in diseased tissue compared to healthy controls.

bioRxiv · Sep 24, 2021Biophysics

Lattice arrangement of myosin filaments correlates with fiber type in rat skeletal muscle

W. Ma, K. H. Lee, S. Yang, T. Irving, R. Craig

The paper uses X-ray diffraction and electron microscopy to show that rat soleus muscle has a simple thick filament lattice, while extensor digitorum longus has a super lattice, correlating with slow and fast fiber types respectively.

bioRxiv · Jul 30, 2019Biophysics

A nanometer difference in myofilament lattice spacing of two cockroach leg muscles explains their different functions

T. N. Tune, W. Ma, T. Irving, S. N. Sponberg

The paper identifies a 1 nm difference in myofilament lattice spacing between two cockroach leg muscles as the cause of their differing functional roles during running.

bioRxiv · May 31, 2019 · PreprintBiophysics