Author

M. Prondzynski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5

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Research Focus:cell type annotation· 4 Organism:human· 3 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

W. T. Pu· 4 shared D. Walker· 2 shared F. Lu· 2 shared K. K. Parker· 2 shared K. Shani· 2 shared L. Carrier· 2 shared M. A. Trembley· 2 shared M. E. Sweat· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCell Biology

W. T. Pu

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5 papers

Recent·Most cited

Efficient and reproducible generation of human iPSC-derived cardiomyocytes using a stirred bioreactor

M. Prondzynski, R. H. Bortolin, P. Berkson, M. A. Trembley, K. Shani, M. E. Sweat, J. Mayourian, N. J. Anyanwu, A. M. Cordoves, Y. Tharani, J. Cotton, J. B. Milosh, D. Walker, Y. Zhang, F. Lu, , W. T. Pu

This paper describes a method to generate high-purity, scalable human iPSC-derived cardiomyocytes using a bioreactor, showing improved viability, function, and consistency compared to traditional methods.

bioRxiv · Feb 24, 2024 · PreprintCell Biology

Imaging of existing and newly translated proteins elucidates mechanisms of sarcomere turnover

G. Douvdevany, I. Erlich, L. Haimovich-Caspi, T. Mashiah, M. Prondzynski, M. R. Pricolo, J. Alegre-Cebollada, W. A. Linke, L. Carrier, I. Kehat

The paper uses imaging to show that sarcomere proteins are replaced by newly translated ones, disproving the existing protein pool model and revealing a unidirectional replacement mechanism.

bioRxiv · Aug 31, 2023Cell Biology

Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy

D. Yoshinaga, R. Feng, M. Prondzynski, K. Shani, Y. Tharani, J. Milosh, D. Walker, K. Carreon, B. M. Boss, K. K. Parker, W. T. Pu, V. J. Bezzerides

This study identifies a mutation in NAA10 causing cardiac arrhythmia and cardiomyopathy by disrupting N-terminal acetylation, and shows potential therapeutic interventions.

bioRxiv · Jul 2, 2023Cell Biology

Tbx5 maintains atrial identity by regulating an atrial enhancer network

M. E. Sweat, Y. Cao, X. Zhang, O. Burnicka-Turek, C. Perez-Cervantes, B. N. Akerberg, Q. Ma, H. Wakimoto, J. M. Gorham, M. K. Song, M. A. Trembley, P. Wang, F. Lu, M. Gianeselli, M. Prondzynski, , W. T. Pu

This study shows Tbx5 maintains atrial identity by regulating an atrial enhancer network through chromatin accessibility and looping.

bioRxiv · Apr 21, 2023Cell Biology

ACTN2 mutant causes proteopathy in human iPSC-derived cardiomyocytes

A. T. Zech, M. Prondzynski, S. R. Singh, N. Pietsch, E. Orthey, E. Alizoti, J. Busch, A. Madsen, C. S. Behrens, M. Meyer-Jens, G. Mearini, M. D. Lemoine, E. Kraemer, D. Mosqueira, S. Virdi, , L. Carrier

This study shows that an ACTN2 mutation leads to proteopathy in human iPSC-derived cardiomyocytes through protein aggregation and activation of proteolytic systems.

bioRxiv · Oct 28, 2021Cell Biology