Author

W. T. Pu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 3 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Prondzynski· 3 shared A. Madsen· 1 shared A. T. Zech· 1 shared B. M. Boss· 1 shared B. N. Akerberg· 1 shared B. Xu· 1 shared C. Guo· 1 shared C. Perez-Cervantes· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersCell Biology

M. Prondzynski

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy

D. Yoshinaga, R. Feng, M. Prondzynski, K. Shani, Y. Tharani, J. Milosh, D. Walker, K. Carreon, B. M. Boss, K. K. Parker, W. T. Pu, V. J. Bezzerides

This study identifies a mutation in NAA10 causing cardiac arrhythmia and cardiomyopathy by disrupting N-terminal acetylation, and shows potential therapeutic interventions.

bioRxiv · Jul 2, 2023Cell Biology

MicroRNA-122-mediated liver detargeting enhances the tissue specificity of cardiac genome editing

L. Yang, C. Guo, Z. Liu, Z. Chen, Y. Sun, X. Hu, Y. Zheng, Y. Li, F. Gao, P. Zhou, W. T. Pu, Y. Guo

This study shows that AAV-Tnnt2 vectors leak into the liver, reducing cardiac specificity, and demonstrates that adding miR122 target sequences reduces this leakiness.

bioRxiv · Jun 29, 2023Physiology

Tbx5 maintains atrial identity by regulating an atrial enhancer network

M. E. Sweat, Y. Cao, X. Zhang, O. Burnicka-Turek, C. Perez-Cervantes, B. N. Akerberg, Q. Ma, H. Wakimoto, J. M. Gorham, M. K. Song, M. A. Trembley, P. Wang, F. Lu, M. Gianeselli, M. Prondzynski, , W. T. Pu

This study shows Tbx5 maintains atrial identity by regulating an atrial enhancer network through chromatin accessibility and looping.

bioRxiv · Apr 21, 2023Cell Biology

ACTN2 mutant causes proteopathy in human iPSC-derived cardiomyocytes

A. T. Zech, M. Prondzynski, S. R. Singh, N. Pietsch, E. Orthey, E. Alizoti, J. Busch, A. Madsen, C. S. Behrens, M. Meyer-Jens, G. Mearini, M. D. Lemoine, E. Kraemer, D. Mosqueira, S. Virdi, , L. Carrier

This study shows that an ACTN2 mutation leads to proteopathy in human iPSC-derived cardiomyocytes through protein aggregation and activation of proteolytic systems.

Cells · Sep 2, 2022Peer-reviewedCell Biology

Selectively expressing SARS-CoV-2 Spike protein S1 subunit in cardiomyocytes induces cardiac hypertrophy in mice.

S. G. Negron, C. W. Kessinger, B. Xu, W. T. Pu, Z. Lin

This study shows that expressing SARS-CoV-2 Spike S1 subunit in cardiomyocytes causes cardiac hypertrophy and inflammation via TLR4 activation, independent of ACE2.

bioRxiv · Jun 20, 2021 · PreprintPathology