Author

M. Scharl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

B. Misselwitz· 3 shared G. Rogler· 3 shared A. Wyss· 2 shared M. R. Spalinger· 2 shared T. Raselli· 2 shared A. N. Santos· 1 shared A. W. Sailer· 1 shared A.W. Sailer· 1 shared

Activity by Year

2018-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

B. Misselwitz

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse Cells

M. R. Spalinger, R. Hai, J. Li, A. N. Santos, T. M. Nordgren, M. L. Tremblay, L. Eckmann, E. Hanson, M. Scharl, X. Wu, B. S. Boland, D. F. McCole

The paper identifies a genetic variant that increases SARS-CoV-2 receptor expression and susceptibility, and shows a JAK inhibitor reduces this risk.

bioRxiv · Dec 9, 2020 · PreprintMicrobiology

The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis

A. Wyss, T. Raselli, G. Schmelczer, G. Klinke, N. Perkins, M. Hersberger, M. R. Spalinger, K. Atrott, S. Lang, I. Frey-Wagner, M. Scharl, A. W. Sailer, O. Pabst, G. Rogler, B. Misselwitz

This study shows that the EBI2-7,25-dihydroxycholesterol axis is induced in colitis and promotes lymphoid structure accumulation during homeostasis and inflammation.

bioRxiv · Sep 24, 2018Immunology

Microbiota stability in healthy individuals after single-dose lactulose challenge - a randomized controlled study

S. Y. Wotzkas, M. Kreuzer, L. Maier, M. Zuend, M. Schlumberger, B. Nguyen, M. Fox, D. Pohl, H. Heinrich, G. Rogler, L. Biedermann, M. Scharl, S. Sunagawa, W.-D. Hardt, B. Misselwitz

This study examines the effect of a single-dose lactulose challenge on gut microbiota stability and E. coli density in healthy individuals, finding no significant changes in E. coli levels or microbiota composition.

bioRxiv · Sep 24, 2018Microbiology

The oxysterol synthesizing enzyme CH25H contributes to the development of intestinal fibrosis

T. Raselli, A. Wyss, M.N. Gonzalez Alvarado, B. Weder, C. Mamie, M.R. Spalinger, W. T. van Haaften, G. Dijkstra, A.W. Sailer, P.H. Imenez Silva, C.A. Wagner, V. Tosevski, Sebastian Leibl, M. Scharl, G. Rogler, , B. Misselwitz

This study shows that the oxysterol synthesizing enzyme CH25H contributes to intestinal fibrosis in Crohn's disease by promoting collagen deposition and fibroblast activity.

bioRxiv · Sep 23, 2018 · PreprintImmunology