Author

M. Siggel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 5 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Assay:cryo-EM· 2 Approach:deep learning· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

G. Hummer· 3 shared J. Kosinski· 3 shared A. Diz-Munoz· 1 shared A. Obarska-Kosinska· 1 shared C. D. Reinkermeier· 1 shared C. J. Chan· 1 shared D. Vasishtan· 1 shared E. A. Lemke· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

G. Hummer

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

What shapes template matching performance in cryogenic electron tomography in situ

V. J. Maurer, M. Siggel, J. Kosinski

The paper evaluates template matching performance in cryo-ET by analyzing how template size, shape, and angular sampling affect ribosome detection in a ground truth dataset.

bioRxiv · Sep 6, 2023 · PreprintBiophysics

The distance between the plasma membrane and the actomyosin cortex acts as a nanogate to control cell surface mechanics

S. Lembo, L. Strauss, W. C. D. Cheng, J. Vermeil, M. Siggel, M. Toro-Nahuelpan, C. J. Chan, J. Kosinski, M. Piel, O. Du Roure, J. Heuvingh, J. Mahamid, A. Diz-Munoz

The paper shows that the distance between the plasma membrane and actomyosin cortex, controlled by MCA proteins, acts as a nanogate regulating actin nucleation and cell surface mechanics.

bioRxiv · Jan 31, 2023 · PreprintBiophysics

Deciphering the conformations and dynamics of FG-nucleoporins in situ

M. Yu, M. Heidari, S. Mikhaleva, P. S. Tan, S. Mingu, R. Hao, C. D. Reinkermeier, A. Obarska-Kosinska, M. Siggel, M. Beck, G. Hummer, E. A. Lemke

This study uses fluorescence microscopy and modeling to reveal the conformation and dynamics of FG-NUPs within the nuclear pore complex, showing good-solvent conditions facilitate transport.

bioRxiv · Jul 7, 2022Biophysics

TriMem: A Parallelized Hybrid Monte Carlo Software for Efficient Simulations of Lipid Membranes

M. Siggel, S. Kehl, K. Reuter, J. Koefinger, G. Hummer

The paper introduces TriMem, a parallelized hybrid Monte Carlo simulation tool for lipid membranes, capable of simulating large and curved sub-cellular structures and validating phase diagrams of vesicles.

bioRxiv · May 25, 2022Biophysics

Form follows function: Variable microtubule architecture in the malaria parasite

J. L. Ferreira, V. Prazak, D. Vasishtan, M. Siggel, F. Hentzschel, E. Pietsch, J. Kosinski, F. Frischknecht, T.-W. Gilberger, K. Grünewald

The paper uses electron cryo-tomography to study microtubule architecture in malaria parasites across their life cycle, revealing structural diversity not seen in other organisms.

bioRxiv · Apr 13, 2022Microbiology

FAM134B-RHD Protein Clustering Drives Spontaneous Budding of Asymmetric Membranes

M. Siggel, R. M. Bhaskara, M. K. Moesser, I. Dikic, G. Hummer

The paper uses molecular dynamics simulations to show that FAM134B-RHD clusters drive membrane budding in the ER, influenced by curvature and bilayer asymmetry.

bioRxiv · Jan 4, 2021Biophysics