F. Qu

Ligand-induced conformational changes in the β1-Adrenergic Receptor Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry

This study uses HDX-MS to analyze structural dynamics of tβ1AR with different ligands, revealing ICL1 dynamics linked to GPCR activation and drug modality.

High-throughput generic single-entity sequencing using droplet microfluidics

This paper introduces GSE-Seq, a high-throughput platform for single-entity sequencing that enables long-read profiling of dsDNA and ssDNA from viruses and bacteria, revealing previously overlooked dark matter and phage-host interactions.

Single-cell mutation rate of turnip crinkle virus (-)-strand replication intermediates

This study estimates the mutation rate of turnip crinkle virus (-)-strand replication intermediates in single cells and supports the BIAS replication model.

Neuronal Activity-Dependent Mechanisms of Small Cell Lung Cancer Progression

This study shows neuronal activity drives SCLC growth in both primary lung tumors and brain metastases through electrical and calcium signaling mechanisms.

Cardiac performance and heat shock response variation related to shell colour morphs in the mudflat snail Batillaria attramentaria

This study compares thermal stress responses and transcriptomic profiles of different shell colour morphs in the snail Batillaria attramentaria, finding that dark morphs exhibit preparative defense strategies and higher cardiac thermal tolerance.

A small DNA virus initiates replication with no more than three genome copies per cell

This study shows DNA viruses like TYLCV undergo intracellular population bottlenecks, limiting replication to no more than three genome copies per cell, ensuring lethal mutations are purged.

Neuronal mimicry generates an ecosystem critical for brain metastatic growth of SCLC

This study shows SCLC cells mimic neurons to promote brain metastasis by recruiting astrocytes through factors like Reelin and SERPINE1.

Axon-like protrusions promote small cell lung cancer migration and metastasis

This study identifies axon-like protrusions in SCLC cells as drivers of migration and metastasis, linking neuronal programs to cancer progression.

Measuring Clinically Relevant Knee Motions With A Self-Calibrated Wearable Sensor

This study validates a low-cost wearable sensor for measuring knee motion during clinical exercises, showing accuracy within 5 degrees for some tasks but larger errors in others.