Author

S. Gurunathan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Assay:metagenomics· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

D. Ercelen· 2 shared K. Cadwell· 2 shared K. K. Jang· 2 shared A. Korman· 1 shared A. M. Keestra-Gounde· 1 shared C. J. Essenburg· 1 shared C. R. Graveel· 1 shared C. Zhou· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

D. Ercelen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness

K. K. Jang, D. Ercelen, J. Y. C. Cen Feng, S. Gurunathan, C. Zhou, A. Korman, L. Newell, D. Hudesman, D. R. Jones, P. Loke, J. E. Axelrad, K. Cadwell

This study uses patient-derived intestinal organoids to predict individual clinical responsiveness to tofacitinib in ulcerative colitis by assessing drug sensitivity and MATE1 expression.

bioRxiv · Mar 2, 2024Cell Biology

Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization

K. K. Jang, T. Heaney, M. London, Y. Ding, F. Yeung, D. Ercelen, Y.-H. Chen, J. Axelrad, S. Gurunathan, A. M. Keestra-Gounde, M. E. Griffin, H. C. Hang, K. Cadwell

The paper shows that overproduction of REG3 proteins in IBD flares reduces Enterococcus faecium, worsening inflammation by disrupting microbiota-immune interactions.

bioRxiv · Jan 29, 2023 · PreprintImmunology

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs

J. L. Grit, L. E. McGee, E. A. Tovar, C. J. Essenburg, E. Wolfrum, I. Beddows, K. Williams, R. Sheridan, J. Schipper, M. Adams, M. Arumugam, T. Vander Woude, S. Gurunathan, J. M. Field, J. Wulfkuhle, , M. Steensma

This study shows p53 loss in NF1-related MPNSTs leads to MET instability, kinome reprogramming, and therapy resistance through altered signaling and lineage plasticity.

bioRxiv · Jan 18, 2023Cancer Biology