Author

M. Tanabe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cancer Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Bartsch· 2 shared A. Munk· 2 shared C. Kattner· 2 shared C. Steinem· 2 shared F. Pein· 2 shared S. Llabres· 2 shared U. Zachariae· 2 shared A. Katagiri· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBiophysics

A. Bartsch

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A novel in silico scaffold-hopping method for drug repositioning in rare and intractable diseases

M. Tanabe, R. Sakate, J. Nakabayashi, K. Tsumura, S. Ohira, K. Iwato, T. Kimura

This paper introduces a novel in silico scaffold-hopping method for drug repositioning, identifying 144 compounds with potential new therapeutic applications for rare diseases.

bioRxiv · Jul 3, 2023 · PreprintPharmacology & Toxicology

Identification of domestic cat hepadnavirus from a cat blood sample in Japan

K. Takahashi, Y. Kaneko, A. Shibanai, S. Yamamoto, A. Katagiri, T. Osuga, Y. Inoue, K. Kuroda, M. Tanabe, T. Okabayashi, K. Naganobu, I. Minobe, A. Saito

The study identifies a domestic cat hepadnavirus infection in a Japanese cat, showing genetic differences from global strains.

bioRxiv · Jan 9, 2022Microbiology

An antibiotic-resistance conferring mutation in a neisserial porin: Structure, ion flux, and ampicillin binding

A. Bartsch, C. M. Ives, C. Kattner, F. Pein, M. Tanabe, A. Munk, U. Zachariae, C. Steinem, S. Llabres

This study shows how a single mutation in Neisseria meningitidis porin PorB affects antibiotic binding and permeability, revealing structural and functional changes in drug resistance.

bioRxiv · Nov 6, 2020Biophysics

De Novo Design of Allosteric Control into Rotary Motor V1-ATPase by Restoring Lost Function

T. Kosugi, T. Iida, M. Tanabe, R. Iino, N. Koga

The paper designs allosteric control into V1-ATPase by restoring lost ATP binding function in pseudo-enzyme subunits, showing tunable acceleration through modulated binding affinity.

bioRxiv · Sep 9, 2020Biophysics

MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells

Y. Takeuchi, T. Murayama, K. Yamawaki, T. Natsume, R.-C. N. Marcela, T. Nishimura, Y. Kogure, A. Nakata, K. Tominaga, A. Sasahara, M. Yano, S. Ishikawa, T. Ohta, K. Ikeda, K. Horie-Inoue, , N. Gotoh

This study shows that MCM10 compensates for c-Myc-induced DNA replication stress in breast cancer stem-like cells, promoting genome duplication and drug resistance.

bioRxiv · Jul 20, 2020Cancer Biology

High-resolution experimental and computational electrophysiology reveals weak β-lactam binding events in the porin PorB

A. Bartsch, S. Llabres, F. Pein, C. Kattner, M. Schön, M. Diehn, M. Tanabe, A. Munk, U. Zachariae, C. Steinem

The paper uses electrophysiology and simulations to study weak β-lactam binding events in the porin PorB.

bioRxiv · Apr 18, 2018Biophysics