Inhibition of CHK2 dependent DNA damage response suppresses Zika virus infection through a STING dependent mechanism
H. Ma, C. Li, Y. Wang, E. V. Valore, M. Trisal, H. Sai-yin Hui, P. Hakimpour, J. R. Bowen, T. W. Mak, M. S. Suthar, B. Pulendran
This study shows that inhibiting CHK2 reduces ZIKV production and rescues developmental defects by enhancing STING-dependent antiviral responses.
bioRxiv · Oct 3, 2022 · PreprintImmunology