K. Rogers

Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection

This paper shows that temporarily blocking type I interferon during viral infection boosts CD8+ T cell memory and vaccine effectiveness by promoting TSCM cell formation.

Soil carbon in the world's tidal marshes

The paper creates the first global, spatially-explicit map of soil organic carbon storage in tidal marshes using environmental data and a new global extent map, estimating total global SOC stock at 1.44 Pg C.

Spatial analysis of Hofbauer cell transcriptome, distribution and morphology in placentas exposed to Plasmodium falciparum

The paper examines spatial transcriptomic and proteomic profiles of Hofbauer cells in placentas with and without past Plasmodium falciparum infection, finding no significant differences in HBC features but reduced fetal vessel development in infected placentas.

Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques.

This study shows that a multi-dose immunization with germline-targeting SOSIP vaccines induces precursor broadly neutralizing antibodies in infant macaques, similar to adult responses.

Aryl amino acetamides prevent the development of Plasmodium falciparum rings via inhibition of the lipid transfer protein PfSTART1

The paper identifies aryl amino acetamides that inhibit Plasmodium falciparum ring development by targeting PfSTART1, a lipid transfer protein, and shows these inhibitors block parasite transmission.

An immunohistochemical atlas of necroptotic pathway expression

The paper develops automated immunohistochemistry protocols to detect necroptotic pathway proteins in mouse and human tissues, revealing heterogeneity and disease-related changes in expression.

Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth

This study identifies Trabid mutations that disrupt APC trafficking and neurite growth by impairing DUB activity or STRIPAK binding, leading to neurodevelopmental defects.

Safety and biodistribution of NanoligomersTM targeting SARS-CoV-2 genome for treatment of COVID-19

This paper evaluates the safety and biodistribution of a novel Nanoligomer targeting SARS-CoV-2 in mice, showing it is safe, nontoxic, and effectively distributed throughout the body.

Durable protection against SARS-CoV-2 Omicron induced by an adjuvanted subunit vaccine

This study shows that an adjuvanted subunit vaccine provides durable protection against SARS-CoV-2 Omicron in non-human primates, with strong neutralizing antibodies and memory T/B cells after booster doses.

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

This study shows that a SARS-CoV-2 RBD nanoparticle vaccine protects against SARS-CoV-2 and related sarbecoviruses, including variants, in mice and non-human primates.

Adjuvanting a subunit SARS-CoV-2 nanoparticle vaccine to induce protective immunity in non-human primates

This study evaluates adjuvants for a subunit SARS-CoV-2 nanoparticle vaccine in non-human primates, showing durable neutralizing antibody responses and protection against infection.

Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression

This study uses transposon mutagenesis to identify genetic drivers of keratinocyte transformation and cutaneous squamous cell carcinoma progression in vivo, revealing both known and novel genes involved in the disease.

TF protein of Sindbis virus antagonizes host type I interferon responses in a palmitoylation-dependent manner

This study shows that Sindbis virus TF protein antagonizes host type I interferon responses, with palmitoylation being essential for this function.

An Erg driven transcriptional program controls B-lymphopoiesis

This study identifies Erg as a critical transcription factor initiating B-lymphopoiesis by regulating gene networks essential for B-cell development and V(D)J recombination.

Vasoactive intestinal peptide confers anticipatory mucosal immunity by regulating ILC3 activity

This study shows that vasoactive intestinal peptide (VIP) regulates ILC3 activity to enhance IL-22 production and confer gut protection through the VIP-VIPR2 pathway.

Toxoplasma gondii bradyzoites induce transcriptional changes to host cells and prevent IFNγ-mediated cell death

This study shows that Toxoplasma gondii bradyzoites alter host cell transcription and prevent IFNγ-mediated cell death through protein export.

TIM-1 SERVES AS A NONREDUNDANT RECEPTOR FOR EBOLA VIRUS, ENHANCING VIREMIA AND PATHOGENESIS

This study shows TIM-1 enhances Ebola virus pathogenesis by increasing virus load and mortality in mice, suggesting TIM-1 as a nonredundant receptor for EBOV.