Author

N. A. J. Krentz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Organism:human· 1

Frequent Co-Authors

A. F. Spigelman· 2 shared A. L. Gloyn· 2 shared H. Sun· 2 shared J. E. Manning Fox· 2 shared P. E. MacDonald· 2 shared A. Bautista· 1 shared A. Jha· 1 shared A. K. Rottner· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPhysiology

A. F. Spigelman

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Author profile →

3 papers

Recent·Most cited

PhysiologyDiabetologiaPeer-reviewedJan 12, 2023

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

K. K. Mattis, N. A. J. Krentz, C. Metzendorf…·A. L. Gloyn

This study shows that loss of RREB1 in beta cells reduces insulin content and affects gene expression, linking RREB1 to diabetes risk through its role in beta cell function and development.

DOI 10.1007/s00125-022-05856-6

humanzebrafish

𝕏 PostBluesky

Cell BiologybioRxivJul 18, 2022

Dynamic Ins2 gene activity defines β-cell maturity states

C. M. J. Chu, H. Modi, S. Skovso…·J. Johnson

This study shows that β-cell heterogeneity in insulin production is due to dynamic Ins2 gene activity states, with high activity linked to maturity and reduced viability.

DOI 10.2337/db21-1065

mousescRNA-seq

𝕏 PostBluesky

PhysiologybioRxivMay 18, 2022

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

T. A. Alghamdi, N. A. J. Krentz, N. Smith…·P. E. MacDonald

This study shows that Zmiz1 is essential for β-cell function and mass expansion in response to high fat feeding, linking its loss to diabetes.

DOI 10.1016/j.molmet.2022.101621

mousebulk RNA-seq

𝕏 PostBluesky