Structural basis of CHMP2A-CHMP3 ESCRT-III polymer assembly and membrane cleavage
K. Azad, D. Guilligay, C. Boscheron…·W. Weissenhorn
This study presents cryo-EM structures of CHMP2A-CHMP3 ESCRT-III filaments and shows they constrict and cleave membrane tubes through electrostatic interactions and VPS4-mediated remodeling.