W. Weissenhorn

This paper develops a drug-inducible tool to inhibit HIV-1 budding by transiently stabilizing ESCRT-III components, showing varying effects on VLP release.

This study presents cryo-EM structures of CHMP2A-CHMP3 ESCRT-III filaments and shows they constrict and cleave membrane tubes through electrostatic interactions and VPS4-mediated remodeling.

This study shows that CdvB1 forms filamentous polymers that are depolymerized by CdvC, and that polymerization and membrane binding are mutually exclusive.

This study develops a synthetic SARS-CoV-2 S glycoprotein virus-like particle vaccine that protects macaques from infection through strong antibody and T cell responses.

This paper presents the crystal structure of HIV-1 gp41 in a fusion intermediate state, revealing conformational plasticity and how antibodies block membrane fusion.

This study investigates how ESCRT-III proteins assemble on curved membranes and induce helical tube formation using in vitro experiments and imaging techniques.

This study compares the membrane interactions of CHMP2A and CHMP2B, finding they have distinct lipid binding preferences and mechanical effects on membranes.

The paper identifies structurally distinct BST2 regions that govern ILT7 activation and pDC responses, showing how mutations in these regions affect immune signaling.