ImmunologybioRxiv
Phostensin Enables Lymphocyte Integrin Activation and Population of Peripheral Lymphoid Organs
H. Lee, H. Sun, F. Lagarrigue…·M. Ginsberg
This study identifies Phostensin as a regulator of integrin activation in lymphocytes by stabilizing the MIT complex through Rap1 dephosphorylation, leading to lymphoid organ population and T cell-mediated colitis.