Author

N. H. Thomae

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Hofmann· 1 shared A. Vulpetti· 1 shared B. Bauer-Probst· 1 shared B. Chung· 1 shared B. Pinch· 1 shared C. R. Thoma· 1 shared D. Begue· 1 shared D. Gorses· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

A. Hofmann

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintApr 9, 2023

Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings

M. Schroeder, M. Renatus, X. Liang…·C. R. Thoma

This study develops DCAF1-based PROTACs to overcome CRBN resistance in targeted protein degradation, demonstrating effective degradation of BTK in CRBN-resistant cells.

DOI 10.1101/2023.04.09.536153

humanproteomics

𝕏 PostBluesky

BiochemistrybioRxivPreprintFeb 1, 2020

Fe-S protein assembly involves bipartite client binding and conformational flexibility in the CIA targeting complex

S. A. Kassube, N. H. Thomae

This study reports crystal and cryo-EM structures of the CIA targeting complex bound to client proteins, revealing a bipartite binding mechanism and conformational flexibility involved in Fe-S cluster transfer.

DOI 10.1101/2020.02.01.930206

cryo-EMexperimental assay

𝕏 PostBluesky