Nanoparticle-mediated Targeting of the Fusion Gene RUNX1/ETO in t(8;21)-positive Acute Myeloid Leukaemia
H. Issa, L. Swart, M. Rasouli…·O. Heidenreich
This study uses siRNA-loaded lipid nanoparticles to target the RUNX1/ETO fusion gene in t(8;21)-AML, showing improved survival and long-term inhibition of leukaemic growth.