MicrobiologybioRxiv
Modulating pathogenesis with Mobile-CRISPRi
O. Rosenberg, J.-X. Qu, N. K. Prasad…·M. Silvis
The paper demonstrates the use of Mobile-CRISPRi to knock down virulence life-style genes in a murine infection model, showing reduced virulence in mice.
DOI 10.1128/jb.00304-19