Author

N. L. Young

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Assay:ChIP-seq· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

F. M. Joseph· 2 shared K. F. Poncha· 2 shared A. Jazayeri· 1 shared A. Vaidya· 1 shared B. C. Taylor· 1 shared B. D. Strahl· 1 shared B. W. Boyle· 1 shared C. Montgomery· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

F. M. Joseph

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Author profile →

3 papers

Recent·Most cited

TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade

Y. Xiong, J. Sharma, M. N. Young, W. Xiong, A. Jazayeri, K. F. Poncha, M. X. Ilagan, Q. Wang, H. Zheng, N. L. Young, M. Sardiello

This study identifies an IKK/β-TrCP2 phosphorylation-ubiquitination cascade that regulates TFEB stability, independent of other regulators.

bioRxiv · Oct 16, 2023Cell Biology

Impact of combinatorial histone modifications on acetyllysine recognition by the ATAD2 and ATAD2B bromodomains

M. Phillips, K. L. Malone, B. W. Boyle, C. Montgomery, I. A. Kressy, F. M. Joseph, K. M. Bright, S. P. Boyson, S. Chang, J. C. Nix, N. L. Young, V. Jeffers, S. E. Frietze, K. C. Glass

This study investigates how ATAD2 and ATAD2B bromodomains recognize acetylated lysine on histones in the presence of other modifications, revealing distinct binding modes and mechanisms.

bioRxiv · Nov 14, 2022Biochemistry

An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability

K. Jain, M. R. Marunde, J. M. Burg, S. L. Gloor, F. M. Joseph, K. F. Poncha, Z. B. Gillespie, K. L. Rodriguez, I. K. Popova, N. W. Hall, A. Vaidya, S. A. Howard, H. F. Taylor, L. Mukhsinova, U. C. Onuoha, , B. D. Strahl

The paper shows that H3 tail acetylation enhances accessibility of both H3K4 methyl readers and writers, revealing an acetylation-mediated chromatin switch that modulates H3K4 methylation read-write capability.

bioRxiv · Feb 28, 2022Biochemistry