K. Jain

Nano-clusters of ligand-activated integrins organize immobile, signalling active, nano-clusters of phosphorylated FAK required for mechanosignalling in focal adhesions

This study shows that nanoclusters of integrins organize phosphorylated FAK nanoclusters in focal adhesions, which are required for mechanosignalling and disassemble in response to inactivation signals.

Intrinsic self-organization of integrin nanoclusters within focal adhesions is required for cellular mechanotransduction

The paper shows that integrin nanoclusters self-organize within focal adhesions at an optimal distance to enable mechanotransduction, with cytoplasmic factors like talin and FHOD1 playing key roles.

Nature and location of modifier alleles determine the resolution of intralocus sexual conflict

The paper investigates how modifier alleles resolve intralocus sexual conflict, finding that imperfect modifiers may not always resolve it and X chromosomes are generally more effective.

When can fitness epistasis be ignored in a polygenic trait at equilibrium?

The paper analyzes how fitness epistasis affects allele frequency distributions in polygenic traits under stabilizing selection and finds parameter regimes where epistasis significantly impacts frequency distributions despite minimal effects on phenotypic quantities.

An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability

The paper shows that H3 tail acetylation enhances accessibility of both H3K4 methyl readers and writers, revealing an acetylation-mediated chromatin switch that modulates H3K4 methylation read-write capability.

Joint effect of changing selection and demography on the site frequency spectrum

The paper analyzes the site frequency spectrum under time-dependent selection and population size changes, showing deviations from equilibrium SFS in certain conditions.

Effect of plant tubulin kinetic diversification on microtubule lengths

The paper investigates how kinetic differences in plant tubulin affect microtubule polymerization, finding that mung bean tubulin produces fewer and shorter filaments with distinct kinetic properties.

Time to fixation in changing environments

The paper examines how fixation times of beneficial and deleterious mutants change in periodically varying environments, finding that beneficial mutations are less affected than recessive deleterious ones.

PRAK-03202: A triple antigen VLP vaccine candidate against SARS CoV-2

This paper develops a triple antigen VLP vaccine candidate, PRAK-03202, against SARS-CoV-2 and shows it induces neutralizing antibodies and Th1 immune responses in mice.

A novel humanized mouse model to study mucosal HIV-1 transmission and prevention

This paper introduces a novel humanized mouse model, CD34T+, which is highly permissive to mucosal HIV-1 infection and can be prevented by broadly neutralizing antibodies.

The impact of dominance on adaptation in changing environments

The paper studies how dominance affects adaptation in changing environments, finding that dominance's impact varies with environmental change rate and mutant fitness dynamics.

Rhizobium desertarenae sp. nov., isolated from the Saline Desert Soil from the Rann of Kachchh, India.

This paper describes the isolation and characterization of a novel Rhizobium species, Rhizobium desertarenae, from saline desert soil in India.

Dynein collective behavior in mitotic nuclear positioning of Saccharomyces cerevisiae

The paper quantifies dynein's role in nuclear positioning during yeast mitosis by modeling SPB mobility and estimating force requirements.

Dominance patterns in dynamic environments

The paper studies how dominance patterns affect mutant fixation probability in changing environments, finding reversed dominance patterns in fast-changing environments.

openPrimeR for multiplex amplification of highly diverse templates

The paper introduces openPrimeR, an R-based tool for designing multiplex PCR primers for highly diverse templates, and demonstrates its effectiveness in amplifying immunoglobulins.

‘Switch-like’ transition from random to directed motility of microtubules by a yeast dynein

The paper investigates how yeast dynein motors transition from random to directed microtubule motility based on motor density and filament length, revealing a switch-like behavior in directionality.