Author

A. Boot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:variant calling· 3 Assay:whole-genome sequencing· 3 Research Focus:variant effect prediction· 2 Research Focus:GWAS / association mapping· 1 Organism:mouse· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

M. N. Huang· 3 shared A. W. T. Ng· 2 shared B. T. Teh· 2 shared S. G. Rozen· 2 shared A. Heguy· 1 shared A. Jusakul· 1 shared A. Ng· 1 shared B. Abedi-Ardekani· 1 shared

Activity by Year

2017-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

M. N. Huang

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3 papers

Recent·Most cited

The Repertoire of Mutational Signatures in Human Cancer

L. Alexandrov, J. Kim, N. J. Haradhvala, M. N. Huang, A. W. T. Ng, Y. Wu, A. Boot, K. R. Covington, D. A. Gordenin, E. Bergstrom, S. M. A. Islam, N. Lopez-Bigas, L. J. Klimczak, J. R. McPherson, S. Morganella, , M. R. Stratton

The paper characterizes 49 mutational signatures in human cancer using a large dataset of somatic mutations, revealing associations with exposures and DNA repair mechanisms and identifying signatures of unknown origin.

bioRxiv · Jul 3, 2019Cancer Biology

In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors

A. Boot, M. N. Huang, A. W. T. Ng, S.-C. Ho, J. Q. Lim, Y. Kawakami, K. Chayama, B. T. Teh, H. Nakagawa, S. G. Rozen

This study identifies the mutational signature of cisplatin in human cell lines and tumors, enabling detection of cisplatin exposure in hepatocellular and esophageal cancers.

bioRxiv · Dec 17, 2017Cancer Biology

Genome-Scale Mutational Signatures Of Aflatoxin In Cells, Mice And Human Tumors

M. N. Huang, W. Yu, W. W. Teoh, M. Ardin, A. Jusakul, A. Ng, A. Boot, B. Abedi-Ardekani, S. Villar, S. S. Myint, R. Othman, S. L. Poon, A. Heguy, M. Olivier, M. Hollstein, , S. Rozen

This study identifies AFB1 mutational signatures across multiple systems and shows their prevalence in HCCs from different regions, highlighting aflatoxin's public health impact.

bioRxiv · Apr 26, 2017Cancer Biology