Author

N. Morrell

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Bradshaw· 1 shared A. H. Baker· 1 shared A. Kurkiewicz· 1 shared A. Shaw· 1 shared Benjamin DunmoreiD· 1 shared C. Delles· 1 shared D. Kelly· 1 shared E. Low· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperCell Biology

A. Bradshaw

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Author profile →

3 papers

Recent·Most cited

Interrogation of the glycolytic axis in pulmonary arterial hypertension models and how modifying these can lead to potential therapeutic options.

Rachel Sutcliffe, Iona Cuthbertson, Stephen Moore, Mark R. Southwood, Benjamin Dunmore, Paul D. Upton, N. Morrell, Paola Lorenza Caruso, Elaine Soon

This paper investigates the glycolytic axis in PAH models and shows that TEPP-46 treatment reduces nuclear PKM2 and improves PAH symptoms in rodent models.

bioRxiv · Jan 14, 2026 · PreprintPhysiology

Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension

G. Emanuelli, J. Zhu, N. Morrell, S. J. Marciniak

The paper functionally validates EIF2AK4 variants in PAH patients, finding some variants are non-pathogenic and others are hypomorphic and responsive to a kinase inhibitor.

bioRxiv · Jan 27, 2024 · PreprintCell Biology

Transforming growth factor-beta signaling via ALK1 and ALK5 regulates distinct functional pathways in vein graft intimal hyperplasia

A. Bradshaw, E. Low, J. T. Schwartze, A. Kurkiewicz, M. Pek, D. Kelly, A. Shaw, M. Thorikay, J. McClure, M. McBride, S. Arias-Rivas, S. E. Francis, N. Morrell, C. Delles, P. Herzyk, , A. H. Baker

This study shows TGF{beta} signals through ALK1 and ALK5 in vein graft SMCs, with ALK5 promoting contractility and ALK1 driving migration, suggesting balancing these pathways could prevent graft failure.

bioRxiv · Nov 29, 2019 · PreprintCell Biology