Cell BiologybioRxiv
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease
DOI 10.1038/s44318-024-00328-6
Author
S. J. Marciniak
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2018-2023 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 12 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship9 papers
Recent·Most cited
- Cell BiologybioRxiv
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
J. Nixon-Abell, F. S. Ruggeri, S. Qamar…·P. St George Hyslop
This study shows ANXA11 biomolecular condensates couple protein and lipid phase states on lysosomal membranes through interactions with ALG2 and CALC.
DOI 10.1038/s41467-025-58142-5 - Cancer BiologybioRxivPreprint
Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma
J. Obacz, R. Nibhani, T. S. Adams…·S. J. Marciniak
This study presents a single-cell transcriptomic atlas of human pleura, identifying stromal heterogeneity and informing in vitro models of mesothelioma.
- PathologybioRxiv
GDF15 antagonism limits severe heart failure and prevents cardiac cachexia in mice
M. Takaoka, J. A. Tadross, A. Al-Hadithi…·J. C. Goodall
This study shows that blocking GDF15 reduces severe heart failure and cardiac cachexia in mice by preventing weight loss and slowing disease progression.
DOI 10.1093/cvr/cvae214 - Cell BiologybioRxivPreprint
Heterozygous transcriptional signatures unmask variable premature termination codon (PTC) burden alongside pathway-specific adaptations in blood outgrowth endothelial cells from patients with nonsense DNA variants causing hereditary hemorrhagic telangiectasia
M. E. Bernabeu-Herrero, D. Patel, A. Bielowka…·C. L. Shovlin
The paper examines the effects of nonsense DNA variants in HHT patients by analyzing transcriptional signatures and PTC burden in BOECs, finding pathway-independent changes in protein modification and stress-related patterns.
DOI 10.1101/2021.12.05.471269 - Cell BiologybioRxiv
Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers
A. Ordonez, H. P. Harding, S. J. Marciniak, D. Ron
This study identifies genes and cargo receptors involved in the ER export of pathogenic α1-antitrypsin polymers using a CRISPR screen.
DOI 10.1016/j.celrep.2021.109144 - Pharmacology & ToxicologybioRxiv
Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin
D. Lomas, J. A. Irving, C. Arico-Muendel…·A. C. Pearce
This study identifies a small molecule that stabilizes Z α1-antitrypsin, reduces polymerization, and increases its secretion in cells and mice.
DOI 10.15252/emmm.202013167 - PhysiologybioRxiv
Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in mice
V. Patel, G. Bidault, J. E. Chambers…·S. J. Marciniak
This study shows that mice lacking PPP1R15A gain less weight and have improved insulin sensitivity on a high-fat diet but not on standard diet.
DOI 10.1038/s41598-019-39562-y - Cell BiologybioRxiv
The integrated stress response regulates BMP signaling through effects on translation
E. Malzer, C. S. Dominicus, J. E. Chambers…·S. J. Marciniak
This study shows that the integrated stress response (ISR) regulates BMP signaling in Drosophila through effects on translation and the transcription factor crc.
DOI 10.1186/s12915-018-0503-x