Author

E. Low

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Ishaq· 2 shared E. Fielder· 2 shared S. Miwa· 2 shared T. von Zglinicki· 2 shared A. Bradshaw· 1 shared A. Calista· 1 shared A. H. Baker· 1 shared A. Kurkiewicz· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

A. Ishaq

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mild uncoupling of mitochondria synergistically enhances senolytic specificity and sensitivity of BH3 mimetics

E. Fielder, A. Ishaq, E. Low, J. Laws, A. Calista, J. Castle, T. von Zglinicki, S. Miwa

This study shows that mild mitochondrial uncoupling enhances the senolytic effectiveness of BH3 mimetics in vitro and in vivo by targeting senescent cell vulnerabilities.

bioRxiv · Aug 23, 2023 · PreprintCell Biology

Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

E. Fielder, T. Wan, G. Alimohammadiha, A. Ishaq, E. Low, M. B. Weigand, G. Kelly, C. Parker, B. Griffin, D. Jurk, V. Korolchuk, T. von Zglinicki, S. Miwa

The paper shows that short anti-senescence interventions reduce radiation-induced frailty and premature ageing in mice, improving muscle, liver function, and memory.

bioRxiv · Dec 15, 2021Cancer Biology

Transforming growth factor-beta signaling via ALK1 and ALK5 regulates distinct functional pathways in vein graft intimal hyperplasia

A. Bradshaw, E. Low, J. T. Schwartze, A. Kurkiewicz, M. Pek, D. Kelly, A. Shaw, M. Thorikay, J. McClure, M. McBride, S. Arias-Rivas, S. E. Francis, N. Morrell, C. Delles, P. Herzyk, , A. H. Baker

This study shows TGF{beta} signals through ALK1 and ALK5 in vein graft SMCs, with ALK5 promoting contractility and ALK1 driving migration, suggesting balancing these pathways could prevent graft failure.

bioRxiv · Nov 29, 2019 · PreprintCell Biology