Maintenance of epithelial traits and resistance to mesenchymal reprogramming promote proliferation in metastatic breast cancer
L. Eichelberger, M. Saini, H. D. Moreno, C. Klein, J. M. Bartsch, M. Falcone, M. Reitberger, E. Espinet, V. Vogel, E. Graf, T. Schwarzmayr, T.-M. Strom, M. Lehmann, M. Koenigshoff, N. Pfarr, , C. H. Scheel
This study shows that high EPCAM expression in metastatic breast cancer cells supports epithelial traits and plasticity, promoting metastatic outgrowth, while loss of epithelial traits inhibits it.
bioRxiv · Mar 19, 2020 · PreprintCancer Biology