M. Saini

Antimalarial and Plasmodium falciparum serpentine receptor 12 targeting effect of a purinergic receptor antagonist FDA approved drug

This study evaluates the antimalarial effect of Prasugrel, an FDA-approved purinergic receptor antagonist, on Plasmodium falciparum by targeting PfSR12, a putative purinergic receptor.

PRAK-03202: A triple antigen VLP vaccine candidate against SARS CoV-2

This paper develops a triple antigen VLP vaccine candidate, PRAK-03202, against SARS-CoV-2 and shows it induces neutralizing antibodies and Th1 immune responses in mice.

Maintenance of epithelial traits and resistance to mesenchymal reprogramming promote proliferation in metastatic breast cancer

This study shows that high EPCAM expression in metastatic breast cancer cells supports epithelial traits and plasticity, promoting metastatic outgrowth, while loss of epithelial traits inhibits it.

Plasmodium falciparum growth is regulated by Sphingosine 1 phosphate produced by Host Erythrocyte Membrane Sphingosine kinase 1

This study inhibits host erythrocyte SphK-1 to reduce S1P levels, which halts Plasmodium falciparum growth and causes cell death by disrupting glycolysis.