C. H. Scheel

A strategy to address dissociation-induced compositional and transcriptional bias for single-cell analysis of the human mammary gland

The paper presents a strategy to minimize dissociation-induced biases in single-cell analysis of human mammary glands by comparing different dissociation methods using single-cell RNA sequencing and flow cytometry.

Transcriptional changes in the mammary gland during lactation revealed by single cell sequencing of cells from human milk

This study uses single-cell RNA sequencing to analyze mammary epithelial cells from human milk and non-lactating breast tissue, identifying distinct luminal cell clusters and their functional differences during lactation.

Maintenance of epithelial traits and resistance to mesenchymal reprogramming promote proliferation in metastatic breast cancer

This study shows that high EPCAM expression in metastatic breast cancer cells supports epithelial traits and plasticity, promoting metastatic outgrowth, while loss of epithelial traits inhibits it.

Cell density-dependent ferroptosis in breast cancer is induced by accumulation of polyunsaturated fatty acid-enriched triacylglycerides

This study shows that low cell density in breast cancer cells increases ferroptosis sensitivity by promoting PUFA-enriched TAG accumulation and reducing lipid desaturation.