N. Rhind

Post-Transcriptional Size-Dependent Expression of the Fission Yeast Cdc13 Cyclin

This study shows that Cdc13 in fission yeast is size-dependent at the protein level but not at the mRNA level, and identifies a motif responsible for this regulation, demonstrating it is not essential for size control.

pomBseen: An Automated Pipeline for Analysis of Fission Yeast Images

pomBseen quantifies fission yeast cells in micrographs with brightfield and fluorescent channels, outputting cell counts, size, and fluorescence intensities.

Short-term molecular consequences of chromosome mis-segregation for genome stability

This study shows that aneuploidy can trigger chromosome instability (CIN) by causing DNA replication stress and continuous CIN, leading to genetically diverse cells with varying proliferation abilities.

Competition for MCM Loading at Origins Establishes Replication Timing Patterns

This study shows that MCM loading at origins determines replication timing, with ORC recruitment and competition for MCM playing key roles.

Fission Yeast Cells Grow Approximately Exponentially

The paper revisits fission yeast cell growth models using time-lapse microscopy and finds exponential growth is a robust approximation despite complexity.

The Fission Yeast S-Phase Cyclin Cig2 Can Drive Mitosis

This study shows that the fission yeast cyclin Cig2 can drive mitosis, challenging the assumption that it is specialized for S-phase regulation and supporting a quantitative model of CDK function.

Replication Fork Slowing And Stalling are Distinct, Checkpoint-Independent Consequences of Replicating Damaged DNA

This paper investigates how DNA damage affects replication fork behavior in fission yeast, finding that the intra-S checkpoint slows replication by inhibiting origin firing but not fork speed, and facilitates lesion bypass while preventing fork stalling.

Size-Dependent Accumulation of the Mitotic Activator Cdc25 as a Mechanism of Size Control in Fission Yeast

This study identifies a size-dependent Cdc25 expression mechanism in fission yeast that regulates cell size by controlling mitotic entry.

An Estradiol-Inducible Promoter Enables Fast, Graduated Control of Gene Expression in Fission Yeast

This paper introduces a new inducible promoter system for fission yeast that enables fast, graduated control of gene expression with a linear dose response.