PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer
X. Lin, S. Roy, M. K. Jolly, F. Bocci, N. Schafer, M.-Y. Tsai, Y. Chen, Y. He, A. Grishaev, K. Weninger, J. Orban, P. Kulkarni, G. Rangarajan, H. Levine, J. N. Onuchic
This study uses molecular dynamics simulations to investigate how phosphorylation of PAGE4 affects its structure and interactions with AP-1 and AR, revealing conformational switching linked to prostate cancer progression.
bioRxiv · Feb 22, 2018Biophysics