Monocytes Mobilized by Gut Neurons Remodel the Enteric Nervous System
S. Kurapati, C. Shin, K. Szabo, Y. Liu, A. Ashraf, B. Koscso, C. Dash, L. Navarro, M. Saha, S. Nagaraj, W. Wang, J. Zhu, N. Shulzhenko, C. Baer, S. Srinivasan, , M. Bogunovic
The paper identifies that post-inflammatory GI dysmotility results from ENS remodeling driven by monocyte recruitment and neuroinflammation, which can be prevented by enhancing HIF1 signaling in enteric neurons.
bioRxiv · Jun 9, 2024 · PreprintImmunology