Cell BiologybioRxivPreprint
Reduced insulin and IGF-1 signalling synergistically extend healthspan in male mice
A. M. N. Walker, N. T. Watt, N. Warmke…·R. M. Cubbon
This study shows that reducing both insulin and IGF-1 signaling in male mice synergistically extends healthspan, as evidenced by longer survival and preserved nesting behavior compared to single-gene knockouts.
DOI 10.1101/579110