M. T. Kearney

The paper identifies a small molecule that inhibits insulin receptor-insulin-like growth factor-1 receptor heterodimers, revealing their distinct physiological role in endothelial cells.

This study shows that reducing both insulin and IGF-1 signaling in male mice synergistically extends healthspan, as evidenced by longer survival and preserved nesting behavior compared to single-gene knockouts.

This study shows that Piezo1 agonist Yoda1 stimulates insulin release from beta-cells and pancreatic islets, suggesting Piezo1's role in cell swelling-induced insulin secretion.