Cell BiologyArteriosclerosis Thrombosis and Vascular BiologyPeer-reviewed
Unlocking the Role of Endothelial MPL Receptor and JAK2V617F Mutation: Insights into Cardiovascular Dysfunction in MPNs and CHIP
Haotian Zhang, Nicholas Kafeiti, Kyla Masarik…·Huichun Zhan
This study shows that JAK2V617F mutations in endothelial cells cause cardiovascular dysfunction by promoting EndMT, and inhibiting the MPL receptor can prevent this effect.